Investigations of Piperazine Derivatives as Intestinal Permeation Enhancers in Isolated Rat Intestinal Tissue Mucosae
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چکیده
منابع مشابه
Intestinal permeation enhancers for oral peptide delivery.
Intestinal permeation enhancers (PEs) are one of the most widely tested strategies to improve oral delivery of therapeutic peptides. This article assesses the intestinal permeation enhancement action of over 250 PEs that have been tested in intestinal delivery models. In depth analysis of pre-clinical data is presented for PEs as components of proprietary delivery systems that have progressed t...
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Per oral delivery of hydrophilic drugs is one of the most challenges in biopharmaceutical research. Hydrophilic drugs show low bioavailability following oral administration because of their poor intestinal permeation. In the last few years great interest has focused on search of different intestinal permeation enhancers for the oral delivery of BCS class iii drugs, small polar molecules, vaccin...
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ژورنال
عنوان ژورنال: The AAPS Journal
سال: 2020
ISSN: 1550-7416
DOI: 10.1208/s12248-020-0416-9